Alisporivir inhibits MERS- and SARS-coronavirus replication in cell culture, but not SARS-coronavirus infection in a mouse model
Identifieur interne : 001084 ( Main/Exploration ); précédent : 001083; suivant : 001085Alisporivir inhibits MERS- and SARS-coronavirus replication in cell culture, but not SARS-coronavirus infection in a mouse model
Auteurs : Adriaan H. De Wilde [Pays-Bas] ; Darryl Falzarano [États-Unis] ; Jessika C. Zevenhoven-Dobbe [Pays-Bas] ; Corrine Beugeling [Pays-Bas] ; Craig Fett [États-Unis] ; Cynthia Martellaro [États-Unis] ; Clara C. Posthuma [Pays-Bas] ; Heinz Feldmann [États-Unis] ; Stanley Perlman [États-Unis] ; Eric J. Snijder [Pays-Bas]Source :
- Virus Research [ 0168-1702 ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Antiviraux (pharmacologie), Cellules cultivées, Ciclosporine (pharmacologie), Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Effet cytopathogène viral (), Humains, Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Lignée cellulaire, Modèles animaux de maladie humaine, Relation dose-effet des médicaments, Réplication virale (), Souris, Syndrome respiratoire aigu sévère (traitement médicamenteux), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (), Virus du SRAS (physiologie).
- MESH :
- pharmacologie : Antiviraux, Ciclosporine.
- physiologie : Coronavirus du syndrome respiratoire du Moyen-Orient, Virus du SRAS.
- traitement médicamenteux : Infections à coronavirus, Syndrome respiratoire aigu sévère.
- virologie : Infections à coronavirus, Syndrome respiratoire aigu sévère.
- Animaux, Cellules cultivées, Coronavirus du syndrome respiratoire du Moyen-Orient, Effet cytopathogène viral, Humains, Lignée cellulaire, Modèles animaux de maladie humaine, Relation dose-effet des médicaments, Réplication virale, Souris, Virus du SRAS.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (pharmacology), Cell Line, Cells, Cultured, Coronavirus Infections (drug therapy), Coronavirus Infections (virology), Cyclosporine (pharmacology), Cytopathogenic Effect, Viral (drug effects), Disease Models, Animal, Dose-Response Relationship, Drug, Humans, Mice, Middle East Respiratory Syndrome Coronavirus (drug effects), Middle East Respiratory Syndrome Coronavirus (physiology), SARS Virus (drug effects), SARS Virus (physiology), Severe Acute Respiratory Syndrome (drug therapy), Severe Acute Respiratory Syndrome (virology), Virus Replication (drug effects).
- MESH :
- chemical , pharmacology : Antiviral Agents, Cyclosporine.
- drug effects : Cytopathogenic Effect, Viral, Middle East Respiratory Syndrome Coronavirus, SARS Virus, Virus Replication.
- drug therapy : Coronavirus Infections, Severe Acute Respiratory Syndrome.
- physiology : Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- virology : Coronavirus Infections, Severe Acute Respiratory Syndrome.
- Animals, Cell Line, Cells, Cultured, Disease Models, Animal, Dose-Response Relationship, Drug, Humans, Mice.
Abstract
In cell culture models, low-micromolar doses of alisporivir block SARS-CoV and MERS-CoV replication. Combination treatment with alisporivir and ribavirin increases the anti-MERS-CoV activity in cell culture. Combination treatment with alisporivir and ribavirin does not protect against SARS-CoV infection in a mouse model. Cyclophilin-binding drugs should be explored further in the context of host-directed anti-coronaviral strategies.
Url:
DOI: 10.1016/j.virusres.2016.11.011
PubMed: 27840112
PubMed Central: 7114565
Affiliations:
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Posthuma</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Feldmann, Heinz" sort="Feldmann, Heinz" uniqKey="Feldmann H" first="Heinz" last="Feldmann">Heinz Feldmann</name><affiliation wicri:level="1"><nlm:aff id="aff0010">National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton</wicri:regionArea><wicri:noRegion>Hamilton</wicri:noRegion></affiliation></author><author><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name><affiliation wicri:level="4"><nlm:aff id="aff0015">Department of Microbiology, University of Iowa, Iowa City, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, University of Iowa, Iowa City</wicri:regionArea><orgName type="university">Université de l'Iowa</orgName><placeName><settlement type="city">Iowa City</settlement><region type="state">Iowa</region></placeName></affiliation></author><author><name sortKey="Snijder, Eric J" sort="Snijder, Eric J" uniqKey="Snijder E" first="Eric J." last="Snijder">Eric J. Snijder</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></analytic><series><title level="j">Virus Research</title><idno type="ISSN">0168-1702</idno><idno type="eISSN">1872-7492</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (pharmacology)</term><term>Cell Line</term><term>Cells, Cultured</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (virology)</term><term>Cyclosporine (pharmacology)</term><term>Cytopathogenic Effect, Viral (drug effects)</term><term>Disease Models, Animal</term><term>Dose-Response Relationship, Drug</term><term>Humans</term><term>Mice</term><term>Middle East Respiratory Syndrome Coronavirus (drug effects)</term><term>Middle East Respiratory Syndrome Coronavirus (physiology)</term><term>SARS Virus (drug effects)</term><term>SARS Virus (physiology)</term><term>Severe Acute Respiratory Syndrome (drug therapy)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Virus Replication (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antiviraux (pharmacologie)</term><term>Cellules cultivées</term><term>Ciclosporine (pharmacologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie)</term><term>Effet cytopathogène viral ()</term><term>Humains</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Infections à coronavirus (virologie)</term><term>Lignée cellulaire</term><term>Modèles animaux de maladie humaine</term><term>Relation dose-effet des médicaments</term><term>Réplication virale ()</term><term>Souris</term><term>Syndrome respiratoire aigu sévère (traitement médicamenteux)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Virus du SRAS ()</term><term>Virus du SRAS (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Cyclosporine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cytopathogenic Effect, Viral</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>SARS Virus</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Ciclosporine</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Cells, Cultured</term><term>Disease Models, Animal</term><term>Dose-Response Relationship, Drug</term><term>Humans</term><term>Mice</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules cultivées</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Effet cytopathogène viral</term><term>Humains</term><term>Lignée cellulaire</term><term>Modèles animaux de maladie humaine</term><term>Relation dose-effet des médicaments</term><term>Réplication virale</term><term>Souris</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">In cell culture models, low-micromolar doses of alisporivir block SARS-CoV and MERS-CoV replication.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">Combination treatment with alisporivir and ribavirin increases the anti-MERS-CoV activity in cell culture.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">Combination treatment with alisporivir and ribavirin does not protect against SARS-CoV infection in a mouse model.</p></list-item><list-item id="lsti0020"><label>•</label><p id="par0020">Cyclophilin-binding drugs should be explored further in the context of host-directed anti-coronaviral strategies.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Al Tawfiq, J A" uniqKey="Al Tawfiq J">J.A. 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Thiel</name></author><author><name sortKey="Davidson, A D" uniqKey="Davidson A">A.D. Davidson</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Pays-Bas</li><li>États-Unis</li></country><region><li>Hollande-Méridionale</li><li>Iowa</li></region><settlement><li>Iowa City</li><li>Leyde</li></settlement><orgName><li>Université de l'Iowa</li></orgName></list><tree><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="De Wilde, Adriaan H" sort="De Wilde, Adriaan H" uniqKey="De Wilde A" first="Adriaan H." last="De Wilde">Adriaan H. De Wilde</name></region><name sortKey="Beugeling, Corrine" sort="Beugeling, Corrine" uniqKey="Beugeling C" first="Corrine" last="Beugeling">Corrine Beugeling</name><name sortKey="Posthuma, Clara C" sort="Posthuma, Clara C" uniqKey="Posthuma C" first="Clara C." last="Posthuma">Clara C. Posthuma</name><name sortKey="Snijder, Eric J" sort="Snijder, Eric J" uniqKey="Snijder E" first="Eric J." last="Snijder">Eric J. Snijder</name><name sortKey="Zevenhoven Dobbe, Jessika C" sort="Zevenhoven Dobbe, Jessika C" uniqKey="Zevenhoven Dobbe J" first="Jessika C." last="Zevenhoven-Dobbe">Jessika C. Zevenhoven-Dobbe</name></country><country name="États-Unis"><noRegion><name sortKey="Falzarano, Darryl" sort="Falzarano, Darryl" uniqKey="Falzarano D" first="Darryl" last="Falzarano">Darryl Falzarano</name></noRegion><name sortKey="Feldmann, Heinz" sort="Feldmann, Heinz" uniqKey="Feldmann H" first="Heinz" last="Feldmann">Heinz Feldmann</name><name sortKey="Fett, Craig" sort="Fett, Craig" uniqKey="Fett C" first="Craig" last="Fett">Craig Fett</name><name sortKey="Martellaro, Cynthia" sort="Martellaro, Cynthia" uniqKey="Martellaro C" first="Cynthia" last="Martellaro">Cynthia Martellaro</name><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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